Xanogen male enhancement – clinical studies, scientific research

To create Xanogen, our team of chemists and formulators drew on the expertise and knowledge of hundreds of scientists, thousands of studies, and tens of thousands of pages of research. We know that many men are interested in learning more about the ingredients in Xanogen, so we’ve provided publication information on the most important articles. 

Please note that the abstracts of all these articles can be found at the National Institute of Health online directory PubMed.  Articles can be ordered from the publisher for a fee, or can be found in a university or medical library.

Epimedium sagittatum for erection enhancement

Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.
Zhonghua Yi Xue Za Zhi. 2004 Jan;84(2):142-5.

Chemical and pharmacological investigations of Epimedium species: a survey.
Prog Drug Res. 2003;60:1-57.

Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in penile cavernosum. Jiang Z, Hu B, Wang J, Tang Q, Tan Y, Xiang J, Liu J. et al.  Journal of Huazhong University Scientific Technology Medical Science.(2006);26(4):460-2.

Epimedium brevicornum Maxim extract relaxes rabbit corpus cavernosum through multitargets on nitric oxide/cyclic guanosine monophosphate signaling pathway. J-H Chiu et. al.  International Journal of Impotence Research (2006) 18, 335–342.

Damiana for sexual enhancement

Arletti, R., et al. “Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual-behavior of male rats." Psychopharmacology. 1999; 143(1): 15–19.

Rowland, D. L., et al. “A review of plant-derived and herbal approaches to the treatment of sexual dysfunctions.” J. Sex Marital Ther. 2003 May-Jun; 29(3): 185-205.

Investigation on the hypoglycaemic effects of extracts of four Mexican medicinal plants ( damiana herb ) in normal and alloxan-diabetic mice. Phytother Res. 2002 Jun;16(4):383-6.

Eldridge J. Bush Medicine in the Exumas and Long Island Bahamas: A field study. Econ Bot . 1975;29(4):307.

Zava, D. T., et al. “Estrogen and progestin bioactivity of foods, herbs and spices.” Proc. Soc. Exp. Biol. Med. 1998; 217(3): 369–78.

Mendes, F., et al. "Brazilian plants as possible adaptogens: An ethnopharmacological survey of books edited in Brazil." J. Ethnopharmacol. 2007 Feb 12; 109(3): 493-500.

Maca as a sexual performance enhancer and fertility enhancer

Cicero, A. F., et al. “Hexanic maca extract improves rat sexual performance more effectively than methanolic and chloroformic maca extracts.” Andrologia. 2002; 34(3): 177–79.

Cicero, A. F., et al. “Lepidium meyenii Walp. improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity.” J. Ethnopharmacol. 2001; 75(2–3): 225–29.

Zheng, B. L., et al. “Effect of a lipidic extract from Lepidium meyenii on sexual behavior in mice and rats." Urology 2000; 55(4): 598–602.

Gonzales, G. F., et al. "Effect of Black maca (Lepidium meyenii) on one spermatogenic cycle in rats." Andrologia. 2006 Oct; 38(5): 166-72.

Bustos-Obregon, E., et al. "Lepidium meyenii (Maca) reduces spermatogenic damage induced by a single dose of malathion in mice." Asian J. Androl. 2005 Mar; 7(1): 71-6.

Ruiz-Luna, A.C., et al. "Lepidium meyenii (Maca) increases litter size in normal adult female mice." Reprod. Biol. Endocrinol. 2005 May; 3(1): 16.

Gonzales, C., et al. "Effect of short-term and long-term treatments with three ecotypes of Lepidium meyenii (MACA) on spermatogenesis in rats." J. Ethnopharmacol. 2006 Feb 20; 103(3): 448-54.

Gonzales, G. F., et al. "Effect of Lepidium meyenii (Maca) on spermatogenesis in male rats acutely exposed to high altitude (4340 m)." J. Endocrinol. 2004; 180(1): 87-95.

Gonzales, G. F., et al. "Lepidium meyenii (maca) improved semen parameters in adult men." Asian J. Androl. 2001; 3(4): 301–3.

Gonzales, G. F., et al. "Effect of Lepidium meyenii (maca) roots on spermatogenesis of male rats." Asian J. Androl. 2001; 3(3): 231–33.

Tongkat ali

Sexual arousal in sexually sluggish old male rats after oral administration of Eurycoma longifolia Jack - tongkat ali. J Basic Clin Physiol Pharmacol. 2004;15(3-4):303-9. Ang HH, Lee KL, Kiyoshi M. School of Pharmaceutical Sciences, University Science Malaysia, Minden, Penang, Malaysia.

Eurycoma longifolia Jack enhances sexual motivation in middle-aged male mice.
J Basic Clin Physiol Pharmacol. 2003;14(3):301-8.

Effects of Eurycoma longifolia Jack ( Tongkat ali ) on sexual qualities in middle aged male rats. Phytomedicine. 2003;10(6-7):590-3.

Effect of Eurycoma longifolia Jack ( Tongkat Ali ) on libido in middle-aged male rats.
J Basic Clin Physiol Pharmacol. 2002;13(3):249-54.

Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia Jack (Tongkat Ali). Fundam Clin Pharmacol. 2001 Aug;15(4):265-8.

Eurycoma longifolia (tongkat ali) increases sexual motivation in sexually naive male rats. Arch Pharm Res. 1998 Dec;21(6):779-81.

L-Arginine

Effects of long-term oral administration of L-arginine on the rat erectile response.  Moody JA, Vernet D, Laidlaw S, Rajfer J, Gonzalez-Cadavid NF.  J Urol. 1997 Sep; 158(3 Pt 1): 942-7.

Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study.  Klotz T, Mathers MJ, Braun M, Bloch W, Engelmann U.  Urol Int. 1999; 63(4): 220-3.

"Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: Results of a double-blind, randomized, placebo-controlled study." Chen, J. et al. (1999).  British Journal of Urology International; 83(3): 269-73.

Tribulus terrestris

The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction - an evaluation using primates, rabbit and rat. Phytomedicine. 2008 January.

Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Sci. 2002 Aug 9;71(12):1385-96.

Cnidium monnier

Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum. Planta Med. 2001 Apr;67(3):282-4.

Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitro. J Urol 2000 Jun;163(6):1975-80.

Put these powerful ingredients to work for you!

Xanogen contains every one of these clinically-tested and proven ingredients in one convenient capsule. You could search the shelves of your local health food store -- but why bother? Xanogen delivers the optimum dosage of potent extracts.

Try Xanogen today and see what a difference a little blue pill can make!